Novel synthetic peptide, process for its preparation and medicam

Details Novel synthetic peptide, process for its preparation and medicam Novel synthetic peptide, process for its preparation and medicam

1984-08-24

1987-08-11

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

C07K 708

Patent

active

046862811

ABSTRACT:
The invention provides a synthetic peptide comprising at least 5 of the 11 amino acids common to the .gamma.chain of sub-unit A of the cholera toxin and the .gamma.chain of the LT toxin of Escherichia coli. The peptide is preferably constituted by a pentadecapeptide which corresponds to the following formula (I): ##STR1## The process of synthesis is by the step by step construction of the peptide chain starting form the C terminal end of said chain, by the successive fixing of the amino acids which constitute the peptide. A novel medicament for the treatment of cholera and infectious gastro-enterites is also disclosed which comprises said synthetic peptide as an active constituent. A diagnosis agent for cholera and/or infectious gastroenterites comprises a sequence of at least the 5 amino acids of the synthetic peptide.

REFERENCES:
patent: 4410514 (1983-10-01), Vale, Jr. et al.
patent: 4415558 (1983-11-01), Vale, Jr. et al.
patent: 4446066 (1984-05-01), Lieyerink
patent: 4457917 (1984-07-01), Schallerneekorrmayer et al.
patent: 4466918 (1984-08-01), Birr et al.
patent: 4474761 (1984-10-01), Caen et al.
patent: 4478827 (1984-10-01), Haber et al.
patent: 4499080 (1985-02-01), Duflot et al.
patent: 4499081 (1985-02-01), Laerum
patent: 4504414 (1985-03-01), Folkers et al.
patent: 4504415 (1985-03-01), Felix et al.
patent: 4515920 (1985-05-01), Erickson
patent: 4520016 (1985-05-01), Hultmark et al.
Zinsser-Microbiology, 17th Edition, (Appleton-Century-Crofts 1980), pp. 735, 751 and 752.

Affiliated with

Also associated with

Rating

Novel synthetic peptide, process for its preparation and medicam does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel synthetic peptide, process for its preparation and medicam, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel synthetic peptide, process for its preparation and medicam will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-403453