Novel synthesis for preparing the hydrochloride salt of selected

Details Novel synthesis for preparing the hydrochloride salt of selected Novel synthesis for preparing the hydrochloride salt of selected

1976-07-09

1977-07-12

Weinberger, Lorraine A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260295R, 260404, 260468H, 260468R, 260469, 260472, 260473R, 260473G, 260476R, C07C 6714

Patent

active

040354059

ABSTRACT:
Compounds of the formula: ##STR1## wherein R represents a straight or branched C.sub.1 -C.sub.5 alkyl group; and R.sub.1 in each occurrence represents an acyl member which is alkanoyl having 1-22 carbon atoms, alkenoyl having one or two double bonds and having 4-22 carbon atoms, ##STR2## having a total of 4-10 carbon atoms of which 3-7 are ring carbon atoms in cycloalkyl and wherein n is zero, one, or two, phenoxyacetyl, naphthalenecarbonyl, pyridinecarbonyl, ##STR3## wherein n is zero, one or two and phenyl is unsubstituted or is substituted by 1-3 alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halo, trifluoromethyl, dialkylamino having 2-8 carbon atoms, or alkanoylamino having 1-6 carbon atoms groups; are prepared in substantial purity and yield, using as the chloride ion donor, cesium chloride (CsCl).
The compounds prepared by the process claimed herein exhibit sympathomimetic activity and are thus useful in eliciting sympathomimetic responses in warm-blooded animals, e.g., reduction in intraocular pressure, miosis, mydriasis, bronchodilation, etc.

REFERENCES:
patent: 3809714 (1974-05-01), Hussain et al.
patent: 3904671 (1975-09-01), Minatoya et al.

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