Novel sugar ureide and thioureide derivatives

Details Novel sugar ureide and thioureide derivatives Novel sugar ureide and thioureide derivatives

1975-02-26

1977-05-24

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 18, 536 22, A61K 3113, C07H 504

Patent

active

040256227

ABSTRACT:
Novel sugar ureide and thioureide derivatives are provided by this invention, which exhibit certain antibacterial activity against a variety of gram-positive and gram-negative bacteria and useful in therapeutic treatment of bacterial infections. The compounds have the formula ##STR1## wherein R.sub.1 is a monovalent residue of aldose, aldonic acid and their 2-amino derivatives, R.sub.2 is an aralkyl, heterocyclic, sulfamoylaryl, R.sub.3 CONH or R.sub.4 NH-- where R.sub.3 is a heterocyclic and R.sub.4 is an aryl group and Y is oxygen or sulfur atom, which are prepared by reacting an isocyanate or isothiocyanate of the formula R.sub.1 NC=Y with an amino compound of the formula R.sub.2 NH.sub.2.

REFERENCES:
patent: 2612497 (1952-09-01), Meijer
patent: 2967859 (1961-01-01), Osipow et al.
patent: 3027364 (1962-03-01), Knoevenagel
patent: 3135748 (1964-06-01), Sheehan
patent: 3149033 (1964-09-01), Clark
patent: 3158598 (1964-11-01), Morel

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