Novel substituted pyrazine, formulations thereof and use in medi

Details Novel substituted pyrazine, formulations thereof and use in medi Novel substituted pyrazine, formulations thereof and use in medi

1990-08-08

1991-12-17

Kilby Scalzo, Catherine S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544409, 544336, C07D45302

Patent

active

050735578

ABSTRACT:
The compound (R)-3-[2-(6-chloropyrazin)yl]-1-azabicyclo[2.2.2]octane and its salts behave as M.sub.1, M.sub.3 muscarinic agonists and are useful in the treatment of neurological and mental disorders, preferably in a pharmaceutical formulation comprising the active compound in association with a pharmaceutically acceptable carrier. The compound can be prepared by via methods analogous to those known in the art and a chiral acid resolution.

REFERENCES:
patent: 4442096 (1984-04-01), Johnston
patent: 4970315 (1990-11-01), Schmidhalter
CAS (Chemical Abstracts Service) vol. 112, 1990, 112:77224q.

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