Novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids a

Details Novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids a Novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids a

1980-05-21

1982-05-04

Chan, Nicky

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260465E, 260508, 260509, 260510, 424315, A61K 31275, A61K 31185, C07C14358, C07C12150

Patent

active

043282440

ABSTRACT:
Novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids having antiviral activity are disclosed. Compounds within the scope of the invention have the formula ##STR1## wherein R.sub.1 represents lower alkyl, lower alkoxy, nitro, amino, cyano, trifluoromethyl, acetyl, methylthio, methylsulfinyl, methylsulfonyl, benzoyl, substituted benzoyl, aminosulfonyl or halogen; and R.sub.2 and R.sub.3 are the same or different and are selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, amino, cyano, trifluoromethyl, acetyl, methylthio, methylsulfinyl, methylsulfonyl, benzoyl, substituted benzoyl, aminosulfonyl or halogen. The invention also includes the pharmaceutically-acceptable salts of the novel (((substituted-phenyl)methyl)amino)benzenesulfonic acids. Methods of using the compounds as antiviral agents are also disclosed, as well as compositions which comprise a carrier in combination with a suitable antiviral active compound.

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patent: 726688 (1903-04-01), Homolka et al.
Badische, Chem. Abstract, 55, 26460e (1960) (Abstract of German Pat. No. 1,076,079).
Borecky, J. Chromatography, 9, 472 (1962).
Borodkin, J. Appl. Chem., USSR, pp. 741-743 (1955).

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