Novel substituted imidazoles, their preparation and use

Details Novel substituted imidazoles, their preparation and use Novel substituted imidazoles, their preparation and use

1984-02-08

1986-07-22

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544238, 544295, 544296, 544328, 544331, 544357, 544370, 546193, 546194, 546256, 546210, 546278, 548337, 548342, 548343, C07D40910, C07D23364

Patent

active

046020934

ABSTRACT:
Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit cardioselective .beta.-adrenergic blocking activity, and are useful as antihypertensive agents, cardioprotective agents, antiarrythmic agents, antianginal agents with reduced side effects; e.g., they are devoid of intrinsic sympathomimetic activity.

REFERENCES:
patent: 4125530 (1978-11-01), Baldwin
patent: 4134983 (1979-01-01), Baldwin
patent: 4199580 (1980-04-01), Baldwin
patent: 4324792 (1982-04-01), Bradshaw
patent: 4355040 (1982-10-01), Furukawa
patent: 4358571 (1982-11-01), Kaufman
patent: 4440774 (1984-04-01), Baldwin
P. J. Machin, et al., J. Med. Chem., 27, 503-509 (1984).

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