Novel substituted anthrasteroid derivatives

Details Novel substituted anthrasteroid derivatives Novel substituted anthrasteroid derivatives

1988-07-07

1989-10-17

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

549432, 558260, 560194, C07C 49617

Patent

active

048748986

ABSTRACT:
Substituted anthrasteroid derivatives represented by the following formula: ##STR1## wherein R is hydrogen or lower alkyl; X is hydrogen, lower alkyl, halogen, hydroxy, hydroxymethyl, or halomethyl; Y is C.dbd.O, CH.about.OR', or OH C R", wherein R' is hydrogen, lower alkyl, cycloalkyl which may have an unsaturated bond or a substituent, or aliphatic lower acyl which may have carboxy or its lower alkyl ester at the terminal; R" is lower alkyl or lower alkynyl; the dotted line indicates the presence or absence of double bond; and the wavy line indicates .alpha. or .beta. configuration; or ketal derivatives thereof being effective against androgen-dependent diseases e.g., prostatic hypertrophy, prostatic cancer.

REFERENCES:
Tetrahedron, vol. 31, 1975, pp. 2237-2242, Pergamon Press, Oxfor, GB; J. C. Jacquesy et al.
Chemical Abstracts, vol. 72, 1970, pp. 368-369, no. 12953n, Columbus, Ohio, US; D. K. Banarjee et al.
Tetrahedron Letters, no. 23, 1968, pp. 2771-2775, Pergamon Press, Oxford, GB; D. K. Banerjee et al.

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