Novel substances KS-504a, KS-504b, KS-504d and KS-504e and proce

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549332, A61R 31335, C07D30308

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active

049121324

ABSTRACT:
Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.

REFERENCES:
patent: 4692310 (1971-03-01), Kase et al.
Chemical Abstracts 106:100841e, "Manufacture of Histamine Release Inhibitor KT5556 with Nocardiopsis", Abstract of JP-61-176,513, (8/8/86).
The Journal of Antibiotics, vol. XXXV, No. 2, pp. 157-163, Studies on New Vasodilators, WS-1228 A and B; H. Tanaka et al.
The Journal of Antibiotics, vol. XXXV, No. 2, pp. 150-156, Studies on New Vasodilators, WS-1228 A and B.
Jpn J. Pharmacol, 43 Suppl. (1987), P-76, P-77 and P-78, p. 202P.

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