Novel styrene derivatives of the general formula

Details Novel styrene derivatives of the general formula Novel styrene derivatives of the general formula

1984-05-14

1985-12-10

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Aluminum containing

544164, 544404, 546297, 548190, 560 30, 560 41, 560104, 562495, 564182, 568308, 568812, 260465R, C07F 506, C07C 6364

Patent

active

045578710

ABSTRACT:
Novel styrene derivatives of the general formula ##STR1## wherein X is hydrogen or halogen, X.sup.1 is halogen, R is hydrogen or methyl, Y is hydroxymethyl, carboxyl, --COOR.sup.1 or --COR.sup.2 wherein R.sup.1 is prenyl, geranyl, farnesyl, cyclohexyl, phthalidyl, straight or branched chain alkyl having 1 to 6 carbon atoms, or said alkyl substituted with hydroxy, methoxy, pyridyl or alkanoyloxy having 2 to 16 carbon atoms, and R.sup.2 is amino, hydroxyamino mono-(or di-)alkylamino in which the alkyl moiety contains 1 or 2 carbon atoms, ethoxycarbonylmethylamino, carboxymethylamino, thiazolylamino, cyclohexylamino, pyridylamino, morpholino, N-methylpiperazino, phenylamino, phenylamino substituted with one or two of halogen, hydroxy, methyl, methoxy, trifluoromethyl or carboxyl at the phenyl ring, and the pharmaceutically acceptable salts thereof when Y is carboxyl are disclosed. These compounds exhibit high and long-lasting anti-inflammatory, analgesic and anti-pyretic activity.

REFERENCES:
patent: 3385886 (1968-05-01), Nicholson et al.

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