Novel steroids

Details Novel steroids Novel steroids

1990-12-24

1992-02-04

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540114, 552519, 552520, 552523, 552526, 552530, 552531, 552540, 552543, 552544, 552548, 552552, 552553, 552554, 552555, 552557, 552599, 552604, 552605, 552607, 552608, 552610, 552611, 552650, 552651, 552632, A61K 3156, C07J 1700, C07J 100, C07J 900, C07J 700, C07J 3100, C07J 400, C07J 1100

Patent

active

050860470

ABSTRACT:
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl, alkylthio and haloalkyl of 1 to 6 carbon atoms, alkenyl and alkynyl of 2 to 6 carbon atoms, optionally substituted arylthio of 6 to 10 carbon atoms, aryl of 6 to 12 carbon atoms, acyl of an organic carboxylic acid of 1 to 12 carbon atoms, --CN, cycloalkyl of 3 to 6 carbon atoms and --(CH.sub.2).sub.m --Re, m is an integer from 1 to 3, Re is --OH or --SH or --Salk, Alk is alkyl of 1 to 6 carbon atoms, X is selected from the group consisting of oxygen, N--O--R.sub.1, ##STR2## or =X is H.sub.2 or ##STR3## R.sub.A and R.sub.B are individually selected from the group consisting of hydrogen, halogen and alkyl of 1 to 6 carbon atoms, R.sub.1 is hydrogen or alkyl of 1 to 6 carbon, R' is hydrogen or acyl, the wavy lines indicate --or -position, Y is selected from the group consisting of oxygen, NOR, ##STR4## or =Y is ##STR5## H.sub.2 and ##STR6## q is an integer from 1 to 3, Rc is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and alkenyl and alkynyl of 2 to 6 carbon atoms, R" is hydrogen or acyl W is selected from the group consisting of hydrogen, optionally substituted alkyl and alkylthio of 1 to 6 carbon atoms and optionally substituted arylthio of 6 to 10 carbon atoms, Z is hydrogen or alkyl of 1 to 10 carbon atoms, n is an integer from 0 to 2, the dotted lines in 1(2)-, 4(5)- and 6(7)-position indicate an optional double bond between the carbon atoms and their non-toxic, pharmaceutically acceptable salts having aromatase specific activity.

REFERENCES:
patent: 4634694 (1987-01-01), Loozen et al.
patent: 5030627 (1991-07-01), Kloosterboer et al.

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