Novel steroid 5.alpha.-reductase inhibitors

Details Novel steroid 5.alpha.-reductase inhibitors Novel steroid 5.alpha.-reductase inhibitors

1980-12-15

1982-03-02

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

260349, 2603975, 2603974, 26023955C, 2603971, 26023955R, A01N 4708, A61K 31655

Patent

active

043178170

ABSTRACT:
Compounds of the following general formula are testosterone 5.alpha.-reductase inhibitors rendering the compounds useful in the treatment of acne and oily skin and benign prostatic hypertrophy: ##STR1## wherein R is: .dbd.O, --OH, --OCO--alkyl C.sub.1-5, --COOH, --CH.sub.2 OH, --COO--alkyl C.sub.1-6, --COCH.sub.3, ##STR2##

REFERENCES:
patent: 3931637 (1976-01-01), Green et al.
patent: 4011315 (1977-03-01), Marx et al.
The Journal of Clinical Investigation, vol. 49 (1970), pp. 1737-1745.
The Journal of Clinical Investigation, vol. 49 (1970), pp. 1746-1753.
The American Journal of Medicine, vol. 62 (1977), pp. 170-190.

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