Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-09-13
1992-04-07
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549363, C07D31914, A61K 3135
Patent
active
051029073
ABSTRACT:
This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
REFERENCES:
patent: 4871721 (1989-10-01), Biller
S. A. Biller et al., J.Med.Chem., 31, 1869 (1988).
C. D. Poulter et al., J. Am. Chem. Soc., 111, 3734 (1989).
E. J. Corey et al., J. Am. Chem. Soc., 98, 1291 (1976).
Bergstrom James D.
Dufresne Claude
Huang Leeyuan
Nallin Mary
Onishi Janet C.
Chang Celia
DiPrima Joseph F.
Ivy C. Warren
Merck & Co. , Inc.
Winokur Melvin
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