Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-04-23
1986-08-19
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3143
Patent
active
046070290
ABSTRACT:
Novel sodium amoxicillin preparations which are easily converted into stable, suitably injectable solutions which are free of allergic reactions-causing chemicals and which contain besides sodium amoxicillin, a small amount of sodium hydroxide and optionally also a small amount of sodium chloride, and a process for their preparation and a process for the preparation of aqueous sodium amoxicillin containing injection solutions. The sodium amoxicillin preparations are prepared by the as fast but gradual addition as possible of an excess of sodium hydroxide to a suspension of amoxicillin trihydrate in water until the amoxicillin has completely dissolved, whereafter optionally a part of the excess of base is immediately neutralized with hydrochloric acid while the temperature is kept between 0.degree.-30.degree. C., followed by sterile filtration of the obtained solution, freezing the solution and freeze drying the obtained solid in flasks or in bulk.
REFERENCES:
patent: 4024244 (1977-05-01), Love
patent: 4029804 (1977-06-01), Clark et al.
Bagerman-Deetman Annita
de Jonge Hayo
Groenendaal Jan W.
Sijbrands Gerrit J.
Gist-Brocades N.V.
Goldberg Jerome D.
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