Novel saframycin A derivatives and process for producing the sam

Details Novel saframycin A derivatives and process for producing the sam Novel saframycin A derivatives and process for producing the sam

1987-09-22

1989-06-06

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435170, 435899, C12P 1718, C12P 104, C12R 156

Patent

active

048371491

ABSTRACT:
Disclosed are compounds of the formula ##STR1## wherein R represents hydrogen or C.sub.1 -C.sub.4 -alkyl. These compounds are obtained by fermentation of the known saframycin A producing strain Streptomyces lavendulae No. 314 and by reaction with the amino acids L-tyrosine, L-methionine, glycine and HOOC-(CH)NH.sub.2 -CH.sub.2 -R. When R is hydrogen, saframycin Y.sub.3 and when R is methyl, saframycin Y.sub.d-1 are produced.

REFERENCES:
patent: 4248863 (1981-02-01), Arai
patent: 4372947 (1983-02-01), Arai et al.
PCT WO85/01049, Mar. 14, 1985.
Antimicrobial Agents and Chemotherapy 28, pp. 5-11, (1985).
J. Antibiotics 37, 847-852 (1984).
Japanese 60 084288, Derwent (Abst. 85-150655/25).
Tetrahedron Letter, 25, pp. 2355-2358 (1979).

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