Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-09-02
1996-09-17
Chan, Nicky
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D31182
Patent
active
055569927
ABSTRACT:
The present invention relates to novel photoactivable rhodamine derivatives for enhancing high quantum-yield production and singlet oxygen generation upon irradiation with light while maintaining desirable differential retention of rhodamine between normal and cancer cells, said derivatives are selected from the group consisting of 4,5-dibromorhodamine 123 (2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid methyl ester hydrochloride); 4, 5-dibromorhodamine 123 (2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid ethyl ester hydrochloride); 4, 5-dibromorhodamine 123 (2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid octhyl ester hydrochloride); 4,5-dibromorhodamine 110 n-butyl ester (2-(4,5-dibromo-6-amino-3-imino-3H-xanthen-9-yl)-benzoic acid n-butyl ester hydrochloride); Rhodamine B n-butyl ester (2-(6-ethyl amino-3-ethyl imino-3H-xanthen-9-yl)-benzoic acid n-butyl ester hydrochloride); and photoactivable derivatives thereof; whereby photoactivation of the derivatives induces cell killing while unactivated derivatives are substantially non-toxic to cells. Also, the present invention relates to the use of the photoactivable derivatives of the present invention for the photodynamic therapy of a cancer patient by destroying human cancer cells, wherein appropriate intracellular levels of the derivatives are achieved and irradiation with light of a suitable wavelength is applied. The present invention also relates to a method for the photodynamic therapy of a patient suffering from leukemias, disseminated multiple myelomas or lymphomas.
REFERENCES:
patent: 4977278 (1990-12-01), Schmeidl
Vora et al., J. Labelled Compd. Radiopharm., 28(1), 1-14 (1990).
Gaboury Louis
Giasson Richard
Gupta Ajay K.
Li Tiechao
Villeneuve Luc
Chan Nicky
Universite de Montreal
LandOfFree
Novel rhodamine derivatives for photodynamic therapy of cancer a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel rhodamine derivatives for photodynamic therapy of cancer a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel rhodamine derivatives for photodynamic therapy of cancer a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-414283