Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Containing at least one abnormal peptide link – e.g. – gamma...
Patent
1986-03-27
1987-11-10
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Containing at least one abnormal peptide link, e.g., gamma...
530331, 530330, 530329, 530328, C07K 502, C07K 506, C07K 508, C07K 510, C07K 706
Patent
active
047058463
ABSTRACT:
The present invention provides novel renin-inhibiting peptides of the formula X-A.sub.6 -B.sub.7 -C.sub.8 -D.sub.9 -E.sub.10 -F.sub.11 -G.sub.12 -H.sub.13 -I.sub.14 -Z, having a lactam pseudo-dipeptide at C.sub.8 -D.sub.9 positions, X and Z are terminal groups, and the remaining variables are absent or are amino acid residues. Such inhibitors are useful for the diagnosis and control of renin-dependent hypertension.
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Holladay et al., "Synthesis of Hydroxyethylene and Ketomethylene Dipeptide Isosteres", Tetrahedron Letters, vol. 24, No. 41, pp. 4401-4404 (1983).
Cox Martha A.
Phillips Delbert R.
The Upjohn Company
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