Novel renin inhibiting peptides having a dihyroxyethylene isoste

Details Novel renin inhibiting peptides having a dihyroxyethylene isoste Novel renin inhibiting peptides having a dihyroxyethylene isoste

1988-08-23

1989-09-05

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530330, 530331, 548533, 548215, 548536, 548200, 548537, 548550, 546243, C07K 706, C07K 506, C07K 508, C07K 510, C07D27704, C07D26302, C07D20700, C07D20712, C07D21136

Patent

active

048640174

ABSTRACT:
The present invention provides novel renin-inhibiting peptides of the formula X-A.sub.6 -B.sub.7 -C.sub.8 -D.sub.9 -E.sub.10 -F.sub.11 -G.sub.12 -H.sub.13 - I.sub.14 -Z, wherein the E.sub.10 -F.sub.11 moiety is a dihydroxyethylene isostere, X and Z are terminal groups, and the remaining variables are absent or are amino acid residues. Such inhibitors are useful for the control of hypertension.

REFERENCES:
patent: 4680284 (1987-07-01), Luly et al.

Affiliated with

Also associated with

Rating

Novel renin inhibiting peptides having a dihyroxyethylene isoste does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel renin inhibiting peptides having a dihyroxyethylene isoste, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel renin inhibiting peptides having a dihyroxyethylene isoste will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-244303