Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1981-06-01
1983-02-22
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435189, 435 25, 424 94, C12P 2100, C12N 902, C12Q 126, A61K 3750
Patent
active
043749283
ABSTRACT:
A novel reductase which is an enzyme that can catalyze the reduction of methionine sulfoxide resides in proteins is described. The enzyme has been found in E. coli, Euglena gracilis, Tetrahymena pyriformis, Hela cells, rat tissue and spinach. The enzyme has an estimated molecular weight of about 18,000-20,000. It can be used to restore biological activity to proteins inactivated by oxidation of methionine residues.
REFERENCES:
Ejiri et al., Analytical Biochemistry, vol. 102, pp. 393-398, (1980).
Ejiri et al., Journal of Bacteriology, vol. 139, No. 1, pp. 161-164, (1979).
Wong et al., Biochemical and Biophysical Research Communications, vol. 96, No. 3, pp. 1449-1454, (1980).
Black et al., J. Biol. Chem. 235, 2910-2916, (1960).
Brot Nathan
Weissbach Herbert
Gould George M.
Hoffmann-La Roche Inc.
Saxe Jon S.
Shapiro Lionel M.
Wilson John B.
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