Novel radioactive estratrienes

Details Novel radioactive estratrienes Novel radioactive estratrienes

1983-12-12

1986-12-30

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 85, 2603975, 26039745, 514182, A61K 4900, A61K 4300

Patent

active

046328203

ABSTRACT:
Novel radioactive .DELTA..sup.4,9,11 -estratrienes marked with iodine 125 or 131 having the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 2 to 12 carbon atoms, R.sub.1 is the reminder of an amino acid of the formula R.sub.1 NH.sub.2 or a derivative thereof being marked with iodine 125 or 131 and the wavy lines indicate the --OR is in the .alpha.- or .beta.-position and the oximido group is in the syn or anti position, a process and intermediates for their preparation, antigens prepared therefrom and use thereof to prepare antibodies.

REFERENCES:
patent: 4323511 (1982-04-01), Varma et al.
patent: 4331646 (1982-05-01), Delaage
"Steroids" (1978) vol. 31, No. 3, pp. 393-406, article by Scott et al.

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