Novel radioactive estradienes

Details Novel radioactive estradienes Novel radioactive estradienes

1984-06-14

1987-04-28

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

540 25, 540 40, C07J 100

Patent

active

046612955

ABSTRACT:
Novel radioactive estradienes labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms and the study and radioimmunological determination of non-radioactive 11.beta.-(4-dimethylaminophenyl)-17.alpha.-(prop-1-ynyl)-.DELTA..sup.4,9 -estradiene-17.beta.-ol-3-one and its metabolites in biological fluids and novel intermediates.

REFERENCES:
patent: 4447424 (1984-05-01), Teutsch et al.
"Steroids", vol. 30, No. 2 (1977) pp. 169-177 and 267-273, articles by Kose K. et al, and Musey et al.

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