Novel quinolonecarboxylic acid derivatives

Details Novel quinolonecarboxylic acid derivatives Novel quinolonecarboxylic acid derivatives

1989-05-22

1991-09-24

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40104, A61K 3147

Patent

active

050515098

ABSTRACT:
Novel compounds of the present invention are represented by the general formula (1) ##STR1## wherein R.sub.1 is hydrogen atom or amino, R.sub.2 is fluorine atom or methoxy, R.sub.3 is hydrogen atom or a lower alkyl having 1 to 3 carbon atoms, and n is 0 or 1. The compounds of the general formula (1) exhibit higher antibacterial activity with fewer side-effects than known quinolone antibiotics such as ofloxacin and norfloxacin. Further, the compounds having the general formula (1) have reduced phototoxicity which normally accompanies 6,8-defluoroquinoline antibiotics.

REFERENCES:
patent: 4771055 (1988-09-01), Domagala et al.
patent: 4777175 (1988-10-01), Culbertson et al.
patent: 4851418 (1989-07-01), Sanchez
patent: 4997943 (1991-03-01), Iwata et al.

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