Novel quaternary salts and method

Details Novel quaternary salts and method Novel quaternary salts and method

1974-06-17

1977-01-04

Thomas, Jr., James O.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 9126

Patent

active

040013278

ABSTRACT:
1-(N-isopropyl-N,N-dimethylamino)-3-(1-naphthoxy)propan-2-ol quaternary salts are useful cardiovascular agents as evidenced by their potent and long-acting anti-arrhythmic, anti-fibrillatory and myocardial ischemia-inhibitory activity. They, furthermore, lack the undesirable side-effects, e.g. .beta.-adrenergic receptor blocking and local anesthetic activity, characteristic of related prior art compounds.

REFERENCES:
patent: 3452102 (1969-06-01), Lednicer
patent: 3658815 (1972-04-01), Fouche
Lucchesi et al., Canadian Jour. Physical Pharm., vol. 44, (1966), pp. 543-550.
Lucchesi et al., N.Y. Acad. of Sci., (1967), pp. 940-950.
Lucchesi et al., J. Pharm. and Exper. Therop., vol. 162, pp. 49-55, (1968).
Lucchesi et al., Federation of American Society for Experimental Biology, vol. 31, No. 2, p. 524, (Mar., 1972).

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