Novel quaternary ammonium salts, compositions and methods for th

Details Novel quaternary ammonium salts, compositions and methods for th Novel quaternary ammonium salts, compositions and methods for th

1975-12-18

1977-09-13

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

128 2A, 250303, 2605676M, 424 9, A61K 2900, A61K 4300, C07C 8730, G01T 1161

Patent

active

040482979

ABSTRACT:
Para-iodobenzyltrimethylammonium iodide is useful as an intermediate in the manufacture of the corresponding compounds wherein the para-iodo atom is enriched with an .sup.123 iodine, .sup.125 iodine or .sup.131 iodine isotope. These radio-iodinated derivatives are valuable adrenal scanning agents in consequence of their propensity to localize in the adrenal gland. Moreover, their ability to bind to catecholamine storage sites accounts for their ability to localize in tissue having a large supply of adrenergic nerves such as spleen and sympathetic ganglia. When injected directly into the cerebrospinal fluid, they concentrate in the choroid plexus and in adrenergic innervated tissues such as the substantia nigra.

REFERENCES:
patent: 3834867 (1974-09-01), Matter et al.
Kojima et al., Chemical Abstracts, vol. 79, No. 3, July 23, 1973, Abstract No. 15079n.
Boura et al., Brit. J. Pharmacol., vol. 17, 1961, pp. 92-100.
Carr et al., Clinical Pharmacology and Therapeutics, vol. 14, 1973, p. 132.
Counsell et al., J. Med. Chem., vol. 16, No. 9, 1963, pp. 1038-1040.

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