Novel pyrroloquinoline alkaloids and methods of use

Details Novel pyrroloquinoline alkaloids and methods of use Novel pyrroloquinoline alkaloids and methods of use

1990-02-16

1991-07-02

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 84, A61K 31445, C07D47102

Patent

active

050286137

ABSTRACT:
The subject invention pertains to novel compounds, batzellines and isobatzellines, isolated from marine sponges. These compounds have been shown to possess antitumor activity. Various derivatives of these compounds have been prepared. The procedures for the isolation of the parent compounds and the preparation of some of their derivatives are described.

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Faulkner, D. J. (1984) Natural Products Reports 1:551-598.
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Uemura, D., K. Takahashi, T. Yamamoto, C. Katayama, J. Tanaka, Y. Okumura, and Y. Hirata (1985) "Norhalichondrin A: An Antitumor Polyether Macrolide from a Marine Sponge," J. Am. Chem. Soc. 107:4796-4798.
Chemical Abstracts, vol. 111: 171348j Batzellines A, B and C. Novel Pyrroloquinoline Alkaloids from the Sponge Batzella sp. Sakemi et al. 11/89.

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