Novel pyrrolizidine alkaloid

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514412, 435184, 435183, 435119, 435200, 548452, C12N 999, C12P 1718, C07D20904, C07D20952

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active

050214276

ABSTRACT:
The present invention involves a purified bioactive compound of the formula: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H or an acyl having less than about five carbon atoms. More specifically the preferred purified bioactive compound is (1R, 1R, 3R, 7S, 7aR)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine.

REFERENCES:
patent: 4454327 (1984-06-01), Butler et al.
patent: 4792558 (1988-12-01), Sunkara et al.
patent: 4849430 (1989-07-01), Fleet et al.
Pan et al., Biochemistry, vol. 22(16), 1983, pp. 3975-3984.
Sunkara et al., Biochemical and Biophysical Research Communications, vol. 148(1), 1987, pp. 206-210.
Walker et al., Proc. Natl. Acad. Sci., vol. 84, 1987, pp. 8120-8124.
Nash et al., Chemical Abstracts, vol. 110(11); Mar. 13, 1989; pp. 411-412; #92034e.
Nash et al., Chemical Abstracts, vol. 109(13); Sep. 26, 1988; p. 370; #107724k.
Elbein et al., Biochemistry 26, 2502-2510 (1987), "Effect of Isomers of Swainsonine on Glycosidase Activity and Glycoprotein Processing".
Nash, et al., "Isolation from Alexa Leiopetala and X-Ray Crystal Structure of Alexine (1R, 2R, 3R, 7S, 8S)-3-Hydroxymethyl-1,2,7-Trihydroxypyrrolizidine [(2R, 3R, 4R, 5S, 6S)-2-Hydroxymethyl-1-Azabicyclo[3.3.0]Octan-3,4,6-Triol], a Unique Pyrrolizidine Alkaloid" Tetrahedron Lett. 29, 2487-2490 (1988).
CRC Handbook of Chemistry and Physics, 5th Edition, 1964, p. c-15.
Hohenschutz et al., Phytochemistry, vol. 20 (1981) 811-814.
Saul et al., Arch. Biochem. Biophys., vol. 221 (1983) 593-597.
Saul et al., Arch. Biochem. Biophys., vol. 230 (1984) 668-675.
Dreyer, et al., J. Chem. Ecol., vol. 11 (1985) 1045-1051.
Nash, et al., Entomol., vol. 42 (1986) 71-77.
Stevens et al., J. Chem. Ecol., vol. 14 (1988) 1467-1473.
Rhinehart et al., Life Sci., vol. 41 (1987) 2325-2331.
Ostrander et al., Can. Res., vol. 48 (1988) 1091-1094.
Molyneux et al., Science, vol. 216 (1982) 190-191.
Colegate et al., Aust. J. Chem., vol. 32 (1979) 2257-2264.
Humphries et al., Can. Res., vol. 48 (1988) 1410-1415.
Molyneux et al., J. Natural Products, vol. 51 (1988) 1198-1206.
Molyneux et al., Arch. Biochem. Biophys., vol. 251 (1986) 450-457.
Evans et al., Tetrahedron Lett., vol. 26 (1985) 1465-1468.
Molyneux et al., in Plant Toxicology, Seawright, Hegarty, James and Keller, ed. Queensland Poisonous Plants Comm., Brisbane, Australia (1985) 266-278.
Sawhney et al., Aust. J. Chem., vol. 27 (1974) 1805-1808.
Tropea et al., 17th Annual Meeting of Society for Complex Carbonhydrates, San Antonio, Texas, Nov. 3-5, 1988, Abstract No. 8.
Saul et al., Proc. Natl. Acad. Sci. U.S.A., vol. 82 (1985) 93-97.
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