Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-11-04
1979-03-06
Randolph, John D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2603068F, 424270, 546 64, A61K 31395, C07D48704
Patent
active
041431421
ABSTRACT:
Compounds of the formula: ##STR1## AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF WHEREIN R, R.sub.1, R.sub.2, R.sub.3, are selected from the group consisting of hydrogen, halogen and lower-alkyl of from one to four carbon atoms, inclusive; with the proviso that taken together they constitute the following substituents on the tetracyclic ring, 10-halo, 8,10-dihalo, 8,9-di-lower-alkyl, and 7,9-dilower-alkyl; R', R'.sub.1, R'.sub.2, and R'.sub.3 are selected from the group consisting of hydrogen, halogen and lower alkyl of from one to four carbon atoms, inclusive, with the proviso that when taken together they constitute the following substituents, 1-halo, 2-halo, 3-halo, 4-halo, 1-lower-alkyl, 2-lower-alkyl, 3-lower-alkyl, 4-lower-alkyl, 1,3-dihalo, 2,3-dihalo, 2,4-dihalo, 3,4-dihalo, 1,3-di-lower-alkyl, 2,3-di-lower-alkyl, 1,4-di-lower-alkyl; R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are selected from the group consisting of hydrogen, halogen and lower-alkyl of from one to four carbon atoms, inclusive, with the proviso that when taken together they constitute the following substituents on the tetracyclic ring, 9-halo, 8-halo, 7-halo, 6-halo, 9-lower-alkyl, 8-lower-alkyl, 7-lower-alkyl, 6-lower-alkyl, 7,9-dihalo, 7,8-dihalo, 6,8-dihalo, 6,7-dihalo, 7,9-di-lower-alkyl, 7,9-di-lower-alkyl, 7,8-di-lower-alkyl, and 4,6-di-lower-alkyl. R.sub.8 is selected from the group consisting of hydrogen, lower-alkyl of from one to four carbon atoms, inclusive, and R.sub.9 is selected from the group consisting of hydrogen and halo. These compounds are useful as anti-hypertensive agents in mammals.
REFERENCES:
matveev, Chem. Abstracts vol. 31, col. 5364.sup.7 (1937).
Pentimalli et al., Chem. Abstracts, vol. 63, col. 14848 (1965).
Almirante et al., J. Med. Chem. vol. 8, pp. 305-312 (1965).
Jen et al., I, J. Med. Chem. vol. 15, pp. 727 to 733 (1972).
Jen et al., II, J. Med. Chem. vol. 16, pp. 407 to 411 (1973).
Adhikary et al., J. Med. Chem. vol. 11, pp. 1352 to 1354 (Dec. 1976).
Randolph John D.
Williams, Jr. Sidney B.
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