Novel protein-immobilizing hydrophobic polymeric membrane, proce

Details Novel protein-immobilizing hydrophobic polymeric membrane, proce Novel protein-immobilizing hydrophobic polymeric membrane, proce

1974-09-16

1976-06-29

Kaplan, G. L.

Chemistry: electrical and wave energy

Processes and products

Vacuum arc discharge coating

195 63, 195 68, 195DIG11, 1951035R, 195127, 204296, 427307, 324 30R, G01N 2730, G01N 2746, G01N 3114, G01N 3316

Patent

active

039665801

ABSTRACT:
A protein-immobilizing hydrophobic polymeric membrane comprising an organic, hydrophobic polymeric substrate with a specific protein reactive group pendant therefrom in preselected concentration is disclosed. The protein reactive groups is a free group of a hydrocarbon chain which has one end thereof absorbed into the surface of said polymeric substrate; said free group, generally at the end of said chain, covalently bonding with a protein molecule. The concentration of protein reactive sites is sufficiently low that the polymeric substrate retains its hydrophobic character. An electrode coated with a protein-immobilized membrane, i.e., a membrane having a hydrocarbon chain to which a protein molecule is attached, provides, in conjunction with a reference electrode, an electrically sensitive system for measuring change in concentration of a compound in solution where said compound selectively reacts with the immobilized protein.

REFERENCES:
patent: 3574062 (1971-04-01), Sato
patent: 3843443 (1974-10-01), Fishman
patent: 3843446 (1974-10-01), Vieth et al.
E. K. Bauman et al., Analytical Chemistry, pp. 1378-1381, vol. 37, No. 11, Oct. 1965.
Klaus Mosbach, Scientific American, pp. 26-33, vol. 224, No. 3, Mar. 1971.

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