Novel prostanoic acid derivatives and processes for the preparat

Details Novel prostanoic acid derivatives and processes for the preparat Novel prostanoic acid derivatives and processes for the preparat

1974-05-23

1976-06-08

Curtis, Allen B.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603407, 2603409, 260468D, C07C17700, C07D31712, C07D31750, C07D31904

Patent

active

039622185

ABSTRACT:
Prostaglandins of the formula ##SPC1##
Wherein R.sub.1 is HOCH.sub.2, --COOH, a salt thereof or an ester thereof; R.sub.2 is OH; and R.sub.3 is H or R.sub.2 and R.sub.3 collectively are = O. A is --CH.sub. 2 --CH.sub.2 -- or --(trans)--CH=CH--, B is --CH.sub. 2 CH.sub.2 --or --(cis)--CH=CH-- and R.sub.4 --O--O--R.sub.5 is a ketal group, are superior in physiological activity to the corresponding 15-.alpha.-hydroxy-prostaglandins.

REFERENCES:
patent: 3639463 (1972-02-01), Pike et al.
patent: 3804880 (1974-04-01), Bergstrom et al.
patent: 3816508 (1974-06-01), Just
patent: 3842118 (1974-10-01), Lincoln, Jr.
patent: 3879423 (1975-04-01), Kelly

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