Novel prostacyclin derivatives and a process for the preparation

Details Novel prostacyclin derivatives and a process for the preparation Novel prostacyclin derivatives and a process for the preparation

1982-02-26

1987-09-08

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 546342, 548562, 549 13, 549 17, 549427, 549501, 556437, 560 56, 560116, 560119, 560256, 562466, 562498, 562501, 564 98, C07C17700, A61K 31557

Patent

active

046924647

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is (a) hydrogen, (b) C.sub.1-10 alkyl, (c) C.sub.1-10 alkyl substituted by halogen; C.sub.1-4 alkoxy; C.sub.6-10 aryl; C.sub.6-10 aryl substituted by 1-3 halogen atoms, a phenyl group, 1-3 C.sub.1-4 alkyl groups or a chloromethyl, fluoromethyl, trifluoromethyl, carboxy, hydroxy or C.sub.1-4 alkoxy group; di-C.sub.1-4 -alkylamino; or tri-C.sub.1-4 -alkylammonium, (d) C.sub.4-10 cycloalkyl, (e) C.sub.4-10 cycloalkyl substituted by C.sub.1-4 alkyl, (f) C.sub.6-10 aryl, (g) C.sub.6-10 aryl substituted by 1-3 halogen atoms, a phenyl group 1-3 C.sub.1-4 alkyl groups or a chloromethyl, fluoromethyl, trifluoromethyl, carboxy, hydroxy or C.sub.1-4 alkoxy group, or (h) an aromatic heterocycle of 5 or 6 ring atoms one of which is O, N or S;

REFERENCES:
patent: 4238414 (1980-12-01), Morton
March Advanced Org. Chem., 2nd Edition, p. 936 (1977).

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