Novel process for producing antibiotics bleomycin

Details Novel process for producing antibiotics bleomycin Novel process for producing antibiotics bleomycin

1979-05-24

1980-12-16

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 260239A, 2603268, 2603451, 536 17R, C07C10352, A61K 3700, C07A 700

Patent

active

RE0304514

ABSTRACT:
A novel process for producing antibiotics bleomycins by innoculating and aerobically culturing in a nutrient source-containing medium a bleomycin-producing strain belonging to the actinomyces, wherein the culture is effected in the presence of an amino compound having at least one ##STR1## group and at least one basic group selected from amino, imino, guanidino, amidino and sulfonium groups and nitrogen-containing cyclic compounds, or in the presence of a compound convertible in the culture liquor to such amino compound as mentioned above, thereby selectively producing a known or novel bleomycin component corresponding to the said amino compound or to an amino compound derived from the above-mentioned compound, and then the known or novel bleomycin is recovered by known means from the culture medium.

REFERENCES:
patent: 3846400 (1974-11-01), Umezawa et al.
Umezawa, Asian Med. J., 13, 190-209, (1970).
Takita et al., Prog. in Antimicro. Anticancer Chemothr., 2, 1031-1036, (1970).
Takita et al., J. of Antibiotics (Tokyo), 22, 237-239, (1969).
Journal of Antibiotics, Aug. 1978, pp. 801-804.

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