Novel process for producing a cephalosporin

Details Novel process for producing a cephalosporin Novel process for producing a cephalosporin

1986-06-24

1988-04-05

Marantz, Sidney

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540225, 540227, C07D50146

Patent

active

047360267

ABSTRACT:
The invention relates to a process for producing a cephalosporin of the formula ##STR1## by reacting the compound ##STR2## with the compound ##STR3## in the presence of boron trifluoride or a complex thereof.

REFERENCES:
patent: 4121026 (1978-10-01), Cheng
patent: 4299829 (1981-11-01), Kamiya
patent: 4460582 (1984-07-01), Nayler
Fieser, "Reagents for Organic Synthesis", vol. 6, p. 67 (1977).
Zaima, Chemical Abstracts, 92:215824g.
March, "Advanced Organic Chemistry", 2nd ed., (1980), p. 388.
M. Ochiai et al., Synthesis and Structure-Activity Relationships of 7beta-[2-(2-Aminothiazol-4-YL)Acetamido]Cephalosporin Derivatives, The Journal of Antibiotics, Feb. 1981, pp. 160-170.
Chemical Abstracts, 82 (1975), 156338v.

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