Novel process for producing 2-ketoethylbenzomorphan derivatives

Details Novel process for producing 2-ketoethylbenzomorphan derivatives Novel process for producing 2-ketoethylbenzomorphan derivatives

1973-05-03

1976-04-13

Todd, G. Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260DIG13, 424267, C07D22126

Patent

active

039503461

ABSTRACT:
2-Ketoethyl-6,7-benzomorphan derivatives of the formula: ##SPC1##
And their pharmaceutically acceptable non-toxic salts, which are useful as non-addictive analgesics and pain-relieving agents and can be prepared by reacting the corresponding 6,7-benzomorphan derivative of the formula: ##SPC2##
With a vinyl carbonyl compound of the formula: ##EQU1## [wherein R' is a hydrogen atom or a group of the formula: --OR" (wherein R" is a hydrogen atom, an alkanoyl group, an alkyl group, an aralkyl group, an alkoxycarbonylmethyl group or a tetrahydropyranyl group), R.sub.1 is a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, R.sub.2 is a hydrogen atom or an alkyl group and A is an alkyl group, an alkoxy group, a substituted or unsubstituted aryl group or a substituted or unsubstituted amino group].

REFERENCES:
patent: 3045023 (1962-07-01), Rorig
patent: 3138603 (1964-06-01), May
patent: 3502688 (1970-03-01), Berger et al.
patent: 3639407 (1972-02-01), Clarke et al.
patent: 3733330 (1973-05-01), Schubert et al.

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