Novel process for preparing 2,2'-cyclocytidine or 1-.beta.-D-ara

Details Novel process for preparing 2,2'-cyclocytidine or 1-.beta.-D-ara Novel process for preparing 2,2'-cyclocytidine or 1-.beta.-D-ara

1975-01-21

1976-04-13

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07H 1702

Patent

active

039503259

ABSTRACT:
2,2'-Cyclocytidine is prepared by reacting cytidine with a functional derivative of silicon, and hydrolyzing the reaction product under acidic conditions. 1-.beta.-D-Arabinofuranosyl cytosine is prepared by reaction of cytidine with a functional derivative of silicon, followed by alkaline hydrolysis of the reaction product. 2,2'-Cyclocytidine and 1-.beta.-D-arabinofuranosyl cytosine are useful as antitumor and antiviral agents.

REFERENCES:
patent: 3322747 (1967-05-01), Shen et al.
patent: 3709874 (1973-01-01), Moffatt et al.

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