Novel process and intermediates useful in the preparation of sym

Details Novel process and intermediates useful in the preparation of sym Novel process and intermediates useful in the preparation of sym

1979-09-24

1981-06-23

Breitenstein, G. T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 1, 560 27, 560 28, 560 49, 560 55, 560 61, 560 65, 560 73, 560100, 560107, 560121, 560122, 560123, 560124, 560138, 560142, 560105, 560106, 560108, 560109, 2603437, 260404, 2604055, 260456A, 260456P, 26050117, 26050118, 424314, 424316, 424263, 546256, 546263, 424280, 546283, 546314, 424308, 546318, 546322, 424311, 546326, 560 63, 424312, C07C125065, C07C 69017

Patent

active

042752191

ABSTRACT:
The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protected aromatic amine; and removing the N-protecting group therefrom.

REFERENCES:
patent: 3809714 (1974-05-01), Hussain et al.
patent: 3825583 (1974-07-01), Hussain et al.
patent: 3839584 (1974-10-01), Hussain et al.
patent: 3868461 (1975-02-01), Hussain et al.
patent: 3908017 (1975-09-01), Hussain et al.
patent: 3933859 (1976-01-01), Kaiser et al.
patent: 3951957 (1976-04-01), von Daeline et al.
patent: 3959485 (1976-05-01), Windheuser
patent: 3966749 (1976-06-01), Bodor et al.
patent: 4002666 (1977-01-01), Shirai et al.
patent: 4031242 (1977-06-01), Jones et al.
patent: 4035405 (1977-07-01), Bodor et al.
patent: 4088783 (1978-05-01), Bodor et al.
patent: 4145441 (1979-03-01), Bodor
patent: 4158005 (1979-06-01), Bodor et al.
Greenstein et al., Chemistry of the Amino Acids, vol. 2, pp. 1027-1048, (1961).
Daeline et al., J. Med. Chem., 13, 607, (1970).
Clayton et al., J. Med. Chem., 19, 1385, (1976).
Jansen et al., J. Chem. Soc., 2127, (1965).
McCurie, Protective Groups in Organic Chem., Plenum Press, N.Y., pp. 58-59, (1973).

Affiliated with

Also associated with

Rating

Novel process and intermediates useful in the preparation of sym does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel process and intermediates useful in the preparation of sym, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel process and intermediates useful in the preparation of sym will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2209135