Novel process and intermediates useful in the preparation of sym

Details Novel process and intermediates useful in the preparation of sym Novel process and intermediates useful in the preparation of sym

1981-02-11

1982-07-06

Breitenstein, G. T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 27, 560 28, 546263, 546314, 546318, 546322, 546326, 260404, 2604045, 2604055, C07C125065

Patent

active

043384552

ABSTRACT:
The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protected aromatic amine; and removing the N-protecting group therefrom.

REFERENCES:
patent: 3843796 (1974-10-01), Miller
patent: 3859331 (1975-01-01), Kaiser et al.
patent: 3875207 (1975-04-01), Iselin et al.
patent: 4041076 (1977-08-01), Avenia et al.
Walker et al., J. Pharm. Sci., 67, No. 4, 558-559, 1978.

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