Novel pregnanoic acid derivatives

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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26039745, 424238, C07J 300

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039563472

ABSTRACT:
Steroids of the formula ##SPC1##
Wherein X is a hydrogen atom, a halogen atom or methyl; Y is a hydrogen atom or a halogen atom; Z is carbonyl, .beta.-acyloxymethylene or, when Y is a hydrogen atom, also methylene; R.sub.1 is a hydrogen atom or methyl; R.sub.2 is a hydrogen atom, an alkali metal atom or optionally substituted hydrocarbon; and --A--B-- is --CH=CH--, --CCl=CH-- or when at least one of X, Y and R.sub.1 is other than a hydrogen atom, --CH.sub.2 --CH.sub.2 --, which can be produced by oxidizing a corresponding 20-hydroxy steroid or a corresponding 21-aldehyde, possess topical anti-inflammatory activity.

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patent: 3463798 (1969-08-01), Godtfredsen et al.
patent: 3766213 (1973-10-01), Furst et al.
patent: 3824260 (1974-07-01), Laurent et al.
patent: 3906095 (1975-09-01), Laurent et al.

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