Novel pregnane-21-oic acid derivatives

Details Novel pregnane-21-oic acid derivatives Novel pregnane-21-oic acid derivatives

1974-12-19

1976-03-16

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424243, C07J 900

Patent

active

039445771

ABSTRACT:
Pregnane-21-oic acids of the formula ##SPC1##
Wherein X is a hydrogen atom, a fluorine atom, or methyl; Y is a hydrogen atom, a fluorine atom, or a chlorine atom; Z is methylene, carbonyl, .beta.-hydroxymethylene, .beta.-acyloxymethylene or when Y is a chlorine atom, .beta.-fluoromethylene or .beta.-chloromethylene; V is methylene, ethylidene or vinylidene; R.sub.1 is a hydrogen atom or acyl, and physiologically acceptable salts thereof with bases and physiologically acceptable 21-esters thereof, possess topical anti-inflammatory activity with substantially no systemic activity.

REFERENCES:
patent: 3828080 (1974-08-01), Phillipps et al.
patent: 3833563 (1974-09-01), Laurent et al.
patent: 3875194 (1975-04-01), Laurent et al.

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