Novel potent inducers of thermal differentiation and method of u

Details Novel potent inducers of thermal differentiation and method of u Novel potent inducers of thermal differentiation and method of u

1989-06-30

1991-10-08

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560171, C07C22924, C07C22926

Patent

active

050556088

ABSTRACT:
The invention provides a class of compounds having two or more nonpolar components connected by a polar group and having polar groups on the termini of the compound.
The invention also concerns a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effect to selectively induce terminal differentiation.
Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity.
Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.

REFERENCES:
patent: 4801748 (1989-01-01), Murahashi et al.
Morrison and Boyd, "Organic Chemistry", 3rd Ed., Allyn and Bacon Inc., p. 755.
Tanaka et al. "Induction of Erythroid Differentiation etc.", Proc. Nat. Acad. Sci. U.S.A., vol. 72, No. 3, pp. 1003-1006, Mar. '75.
Reuben et al. "Inducers of Erythroleukemic Differentiation,", Journal of Biol. Chem. vol. 253, No. 12, pp. 4214-4218, Jun. 78.

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