Novel polypeptides with a blood coagulation-inhibiting action, p

Details Novel polypeptides with a blood coagulation-inhibiting action, p Novel polypeptides with a blood coagulation-inhibiting action, p

1986-07-15

1988-12-13

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530324, A61K 3702, C07K 710

Patent

active

047911000

ABSTRACT:
The invention relates to a polypeptide of the formula ##STR1## in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.

REFERENCES:
patent: 4654302 (1987-03-01), Fritz et al.
patent: 4668662 (1987-05-01), Tripier
Jutisz et al., Purification De L'Hirudine, Bull. Soc. Chim. Biol. vol. 45, No. 1, (1963), pp. 55-67.
Methods in Enzymology, vol. XLV, Part B (1975), pp. 669-678.
Markwardt et al., Reindarstellung und Analyse des Thrombininhibitors Hirudin, Hopp-Seyler's Z/ Physiol. Chem., Bd. 348 (1967), pp. 1381-1386.

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