Novel platinum complexes

Details Novel platinum complexes Novel platinum complexes

1984-10-16

1986-08-19

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C07F 1500

Patent

active

046071148

ABSTRACT:
This invention relates to a novel platinum-diamine complexes represented by the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents a lower alkyl group having 1 to 3 carbon atoms or jointly represent an alkylene group having 3 to 6 carbon atoms; two X's each represents a halogen atom, ##STR2## or jointly represent a group represented by ##STR3## in which R.sub.3 is a lower alkyl group or a group represented by --OM (wherein M is an atom which can become a monovalent cation); Y is --OH or a halogen atom; and n is 0 or 1, and n is 1 when R.sub.1 and R.sub.2 jointly represent an alkylene group having 5 carbon atoms and X is chlorine. The platinum-diamine complex of this invention has an excellent antitumor activity and a lower renal toxicity than cis-Platin now widely used as a carcinostatic as clinical medicine, and is expected as a carcinostatic lowered in toxicity.

REFERENCES:
patent: 4255347 (1981-03-01), Kidani et al.
patent: 4431666 (1984-02-01), Bulten et al.
patent: 4466924 (1984-08-01), Verbeek et al.
patent: 4482569 (1984-11-01), Bulten et al.
Chemical Abstracts 91 116493w (1979).
Chemical Abstracts, 71 34905e (1969).
Chemical Abstracts 73 1997/w (1970).
Chemical Abstracts 81 113304t (1974).
Leh, Francis K. V. and Walter Wolf, Journal of Pharmaceutical Sciences, "Platinum Complexes: A New Class of Antineoplastic Agents", vol. 65, No. 3, 315-328 (1976).
Hall et al., Journal of Inorganic Biochemistry, "Unsymmetrical C-Substituted Ethylenediamine Platinum Coordination Complexes: Synthesis and Activity Against Mouse Leukemia L1210", vol. 11, 139-149 (1979).

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