Novel platinum complex, antineoplastic agent containing the same

Details Novel platinum complex, antineoplastic agent containing the same Novel platinum complex, antineoplastic agent containing the same

1989-12-14

1990-11-06

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548402, A61K 31555, C07D20714, C07D21156

Patent

active

049688006

ABSTRACT:
A platinum complex of the formula ##STR1## wherein n is 1 or 2 and X is chlorine, bromine or iodine is described, which is useful intermediate; thus, it can be reacted with silver nitrate or silver sulfate and the resulting compound can be treated with an anion exchange resin or barium hyroxide to give a compound of the formula ##STR2## which can then be reacted with glycolic acid to furnish a compound of the formula ##STR3## wherein n is 1 or 2 and A is --OCOCH.sub.2 O--; these products are useful antineoplastic agents.

REFERENCES:
patent: 4575550 (1986-03-01), Totani

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