Novel platinum complex

Details Novel platinum complex Novel platinum complex

1989-10-06

1990-11-06

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

C07F 1500

Patent

active

049688251

ABSTRACT:
A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.

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patent: 4870070 (1989-09-01), Bitha et al.
Appleton, T. G. & Hall, J. R., Inorganic Chemistry, vol. II, No. 1, 1972, pp. 112-117.
Chemico--Biological Interactions, vol. 46, No. 2, 1983, pp. 219-232, Elsevier Scientific Publishers Ireland Ltd, GB; B. Das Sarma et al.: "Platinum Complexes with Anticancer Potential and Their Evaluation by a Colorimetric Lambda Prophage Induction Assay", *p. 222, Compound 24*.

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