Novel plasminogen activator and its preparation process

Details Novel plasminogen activator and its preparation process Novel plasminogen activator and its preparation process

1988-06-30

1990-09-18

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 435219, 435815, 424 9464, C12N 964

Patent

active

049578642

ABSTRACT:
A novel plasminogen activator having specific properties. The plasminogen activator can be prepared by subjecting a human kidney or human blood vessel to an extraction treatment with an ammonium thiocyanate solution and then allowing the resultant extract to pass through a column of ion exchanger, a metal chelate column, a column of L-arginine or an arginine derivative supported on a carrier, or a column of a carrier having properties as a molecular sieve to purify the same. The plasminogen activator exhibits a strong thrombolytic activity and is useful as an active ingredient of a thrombolytic composition accompanied with a minimum of side effects.

REFERENCES:
patent: 4245051 (1981-01-01), Reich
patent: 4317823 (1982-03-01), Horiguchi
patent: 4381346 (1983-04-01), Husain
Sueishi, K. et al., Bioch. Biophys. Acta., 717:327-336, (1982).
Weimar, W. et al., The Lancet, Nov. 7, 1981, pp. 1018-1020.
Rijken, D. C. et al., J. Biol. Chem., 256(13):7035-7041, (7-1981).
Husain, S. S. et al., Proc. Natl. Acad. Sci., U.S.A., 78(7):4265-4269, (7-1981).
Aasted, B. et al., Biochim. Biophys. Acta., 621:241-254, (1980).
Binder, B. R. et al., J. Biol. Chem., 254(6):1998-2003, (1979).
Rijken, D. C. et al., (1979), Biochim. Biophys. Acta., 580, 140-153.
Rijken, D. C. et al., (1982), J. Biol. Chem., 257, 2920-2925.

Affiliated with

Also associated with

Rating

Novel plasminogen activator and its preparation process does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel plasminogen activator and its preparation process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel plasminogen activator and its preparation process will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1572380