Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1986-05-02
1987-12-01
Schain, Howard E.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
530352, C12N 912
Patent
active
047104694
ABSTRACT:
A glycoprotein phosphotyrosyl protein phosphatase is isolated from human tissues, such as human placental membrane. Upon membrane solubilization and extraction of the enzyme it was subjected to chromatographic purification and isolation. The analytical and biological responses of the enzyme demonstrate that it is novel and readily distinguished from other enzymes previously isolated from similar tissues. The enzyme is a dephosphorylation enzyme of membrane phosphoprotein kinases, and as such has utility as an antidiabetic agent, an antiatherosclerosis agent or an antitumor agent since certain membrane receptor kinases involved in each such biological function involve a phosphorylation mechanism for cell transformation, metabolism and growth and which, when blocked by the instant enzyme, results in a suppression or alteration of the biological function.
REFERENCES:
Shriver et al., J. Bio. Chem., 259, pp. 11383-11399 (1984).
Swarup et al., J. Biol. Chem., 256, pp. 8187-8201 (1981).
Li et al., Eur. J. Biochem., 138, pp. 45-51 (1984).
Foulkes et al., J. Biol Chem., 258, pp. 431-438 (1983).
Chernoff et al., Arch. Biochem. Biophys., 226, pp. 517-550 (1983).
Brautigan et al., J. Biol. Chem., 256, pp. 6519-6522 (1981).
Liang Theming
Slater Eve E.
Merck & Co. , Inc.
Rose David L.
Schain Howard E.
Sudol, Jr. Michael C.
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