Novel phenethylamine derivatives and processes for preparing sam

Details Novel phenethylamine derivatives and processes for preparing sam Novel phenethylamine derivatives and processes for preparing sam

1979-06-06

1980-10-14

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260463, A61K 31265, C07C 6996

Patent

active

042281830

ABSTRACT:
A compound of the formula: ##STR1## wherein R is methyl or 2-methylthioethyl, is prepared by either (A) condensing a compound of the formula: ##STR2## wherein R is the same as above, or a reactive derivative thereof with 3,4-diethoxycarboxyphenethylamine, or (B) condensing the compound (II) or a reactive derivative thereof with dopamine, followed by reacting the resultant product with an ethoxycarbonyl halide. The compound (I) shows potent renal blood flow-increasing activity and is useful for the treatment of renal hypertension, congestive heart failure and other diseases due to renal blood flow disturbances.

REFERENCES:
patent: 2400038 (1946-05-01), Buck et al.
patent: 3801624 (1974-04-01), Biel et al.
patent: 3869492 (1975-03-01), Biel et al.
patent: 4033997 (1977-07-01), Roteman
patent: 4051169 (1977-09-01), Saari
R. Morrison et al., Organic Chemistry, Allyn & Bacon, Inc. Boston (1967), pp. 954-956.
Abstract of Amer. Chem. Soc. (Div. of Med. Chem.) 165 Nat'l. Meeting No. 11 (1973).
Pharmacologist 16, 268 (1974).

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