Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-08-04
1988-01-26
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3155
Patent
active
047217090
ABSTRACT:
Pharmaceutical compositions are disclosed which contain hydrophobic practically water-insoluble drugs adsorbed onto carriers such as starch and/or microcrystalline cellulose. The rate of dissolution and absorption in the body is improved due to the very fine particle size of the drug adsorbed onto the carriers. The drug particles have a mean size of less than 10 microns the size distribution of particles being such that at least 95% of particles are smaller than 15 microns. A process for the preparation of drug-carrier adsorbates and their incorporation in pharmaceutical compositions is also disclosed. The use of such compositions to treat mammals is also disclosed.
REFERENCES:
Merck Index, 9th Ed. (1976), p. 898.
Chem. Abst. 99-27931K (1983); 99-110596A (1983) and 100-1978175 (1984).
Tulakhar et al; J. Pharm. Pharmacol, 1983, 35:269-274.
Sandersen et al., J. Pharm. Pharmacol, 1984, 36 789-795.
Seth Pawan
Seth Pyare
Friedman Stanley J.
Lewen Bert J.
Sternberg Henry
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