Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1979-12-28
1982-02-23
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
043168892
ABSTRACT:
Novel peptidyl-arginine aldehyde derivatives and their salts of formula I, ##STR1## wherein X represents a hydrogen atom, benzoyl or tert-butyloxycarbonyl group, and Y is a D-phenylalanine, .beta.-phenyl-D-lactic acid or D-allo-isoleucine moiety, are prepared from peptidyl-arginine aldehydes protected by an urethane type protecting group on their N- or O-terminal and/or a guanidino group, by removing the protecting group in a mixture of lower alkanols and water by means of hydrogenolysis, and eventually converting the product formed into a salt.
The compounds of formula I possess valuable antithrombin activity.
REFERENCES:
Chem. Abstr. vol. 83, 1975, p. 10882s.
Bagdy Daniel
Bajusz Sandor
Barabas Eva
Szell nee Hasenohrl Erzsebet
Phillips Delbert R.
Richter Gedeon Vegyeszeti Gyar Rt.
Ross Karl F.
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