Novel peptides suppressing the function of the immune system, ph

Details Novel peptides suppressing the function of the immune system, ph Novel peptides suppressing the function of the immune system, ph

1989-06-13

1991-04-16

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, 530331, A61K 3702, C07K 508, C07K 510

Patent

active

050082469

ABSTRACT:
The invention relates to novel peptides and their acid addition salts, suppressing the function of the immune system, pharmaceutical compositions containing these peptides as well as to a process for preparing these peptides and compositions. The peptides are represented by formulae (1) to (16): ##STR1## The novel peptides are useful for the therapy of diseases where a decrease in the activity of the immune system is desirable.

REFERENCES:
patent: 4505853 (1985-03-01), Goldstein et al.
Denes et al., Chem. Abstracts. 107(19):169209p.
Szokan et al., 7th Int. Symp. on HPLC of Prot., Pep., & Polynuc. II, Nov. 2-4, 1987, pp. 115-122.
Denes et al., Therapeutic Possibilities of Thympoietin Fragments (TP 3 and TP 4) Based on Experimental Animal Models, Drugs Exptl. Clin. Res., XIII (5), 279-287 (1987).
Gorog et al., II. Detection and Quantification of a Diastereomeric Impurity in the Peptide RGH-0205 (Arg-Lys-Asp), Journal of Chromatography, 452, pp. 317-321.

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