Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1981-07-10
1983-09-20
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125E, A61K 3700, C07C10352
Patent
active
044056079
ABSTRACT:
Pentapeptides of formula I, ##STR1## wherein Z.sup.1 =H, CH.sub.3 or amidino; R.sub.1 =H or alkyl and R.sub.2 =H or R.sub.1 +R.sub.2 =--CH.sub.2 --CH.sub.2 --; R.sub.3 =m- or p--OH or -alkoxy; B=residue of a (D)-.alpha.-amino acid; R.sub.4 =H or alkyl; Z.sup.2 =optionally substituted phenyl; and E=.beta.-amino alcohol residue (whereby when Z.sup.1 =H or CH.sub.3, R.sub.4 =C.sub.3-4 -alkyl) as well as their esters and the acid addition salts and complexes of such peptides and esters. Compounds according to the invention have valuable pharmacological, in particular LH-secretion inhibiting activity.
REFERENCES:
patent: 4254023 (1981-03-01), Stewart et al.
patent: 4261888 (1981-04-01), Bauer et al.
patent: 4283329 (1981-08-01), Gesellchen et al.
patent: 4322339 (1982-03-01), Gesellchen et al.
Biol. Abstr. 70, 66983.
Cardinaux Francois
Huguenin Rene
Pless Janos
Honor Robert S.
McGovern Thomas O.
Phillips Delbert R.
Sandoz Ltd.
Sharkin Gerald D.
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