Novel oxopyrimidine derivatives, pharmaceutical compositions con

Details Novel oxopyrimidine derivatives, pharmaceutical compositions con Novel oxopyrimidine derivatives, pharmaceutical compositions con

1984-09-05

1986-12-09

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514906, 544302, 544303, 544305, A61K 31515, C07D23962, C07D23964

Patent

active

046280561

ABSTRACT:
There are disclosed novel oxopyrimidine derivatives of the general formula ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and are each hydrogen or lower alkyl optionally substituted by lower alkoxy, and R.sub.3 and R.sub.4 may be the same or different and are each phenyl optionally substituted by lower alkyl or halogen, provided that when R.sub.1 and R.sub.2 are both hydrogen, R.sub.3 and R.sub.4 are each substituted phenyl. Pharmaceutical compositions containing these compounds and their use as anticonvulsant, antianxiety and muscle relaxant agents are described.

REFERENCES:
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Raines et al., Journal of Pharmacology and Exp. Ther. vol. 186, No. 2, pp. 315-322, (1973).
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Raines et al., Chemical Abstracts, 92:174402x, 1980.
Weinryb et al., Chemical Abstracts, 76:1206c, 1972.
Stavber et al., Chemical Abstracts, 99:157381s, 1983.
McElvain, Journal of the American Chemical Society vol. 57, pp. 1303-1304, 1935.
Samour et al., Journal of Medicinal Chemistry, vol. 14, pp. 187-189, 1971.

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